Diabetes drug may help treat Alzheimer's: study

Jan 1:A drug created to treat type 2 diabetes could be used to fight Alzheimer's disease, say scientists who found that the medicine significantly reversed memory loss in mice. The research, published in the journal Brain Research, could bring substantial improvements in the treatment of Alzheimer's disease through the use of a drug originally created to treat type 2 diabetes. The treatment "holds clear promise of being developed into a new treatment for chronic neurodegenerative disorders such as Alzheimer's disease," said Professor Christian Holscher from Lancaster University in the UK.
Alzheimer's disease is the most common cause of dementia and the numbers are expected to rise to two million people in the UK by 2051 according to Alzheimer's Society, who part- funded the research. Although the benefits of these 'triple agonist' drugs have so far only been found in mice, other studies with existing diabetes drugs such as liraglutide have shown real promise for people with Alzheimer's, so further development of this work is crucial. This is the first time that a triple receptor drug has been used which acts in multiple ways to protect the brain from degeneration.
It combines GLP-1, GIP and Glucagon which are all growth factors. Problems with growth factor signalling have been shown to be impaired in the brains of Alzheimer's patients. The study used APP/PS1 mice, which are transgenic mice that express human mutated genes that cause Alzheimer's. Those genes have been found in people who have a form of Alzheimer's that can be inherited. Aged transgenic mice in the advanced stages of neurodegeneration were treated. In a maze test, learning and memory formation were much improved by the drug which also enhanced levels of a brain growth factor which protects nerve cell functioning. It also reduced the amount of amyloid plaques in the brain linked with Alzheimer's, chronic inflammation and oxidative stress.
The drug also slowed down the rate of nerve cell loss. "These very promising outcomes demonstrate the efficacy of these novel multiple receptor drugs that originally were developed to treat type 2 diabetes but have shown consistent neuro- protective effects in several studies," said Holscher. "Clinical studies with an older version of this drug type already showed very promising results in people with Alzheimer's disease or with mood disorders," he said. "Here we show that a novel triple receptor drug shows promise as a potential treatment for Alzheimer's but further dose-response tests and direct comparisons with other drugs have to be conducted in order to evaluate if this new drugs is superior to previous ones," he added.
Type 2 diabetes is a risk factor for Alzheimer's and has been implicated in the progression of the disease. Insulin desensitisation has also been observed in the Alzheimer's disease brain. The desensitisation could play a role in the development of neurodegenerative disorders as insulin is a growth factor with neuroprotective properties. Agencies
Source: Agencies


  
  

Comments


MichaelDen says...
cialis cheapest lowest price buy cialis online cheap cialis nz cialis order cialis online no prescription canada cialis usa cialis brand name buy online cialis usa cialis pills for women

Richardhut says...
cialis daily for sale cialis online cialis buy over counter buy cialis cialis soft tabs 20mg pills cialis usa where can i order cialis cialis pills buy cialis vegas

BrettKix says...
buying viagra online uk erectile dysfunction remedies when will viagra be generic sex pills buy genuine viagra erection pills generic viagra comparison erectile dysfunction pills cialis pills cut half

Jerryked says...
buy cialis soft online cialis 20mg prix en pharmacie buy black cialis online cialis 20mg prix en pharmacie buy cialis today cialis generico buy generic cialis online usa cialis 20 mg where to order cialis

Jameshiego says...
buy generic cialis uk cialis online order cialis online uk cialis cheap cialis fast generic cialis online without script can cialis pills cut buy generic cialis online how to buy cialis in australia

GeorgeSnady says...
order cialis online cheap buy cialis cheap cialis uk generic cialis coupon cheaper viagra cialis levitra generic cialis cheap cialis online pharmacy prescription cialis generic buy viagra cialis or levitra

Claudehor says...
price viagra mumbai generic viagra safe generic viagra online buy generic viagra generico viagra mexico viagra without a doctor's prescription happens you take 100mg viagra viagra without doctor order real viagra online

Henryarilk says...
cheap viagra online usa buy generic viagra buy viagra walgreens generic viagra 100mg buy online viagra viagra viagra without doctor viagra buy thailand viagra without a doctor prescription where can i buy viagra in new zealand

RobertPaw says...
levitra discount canada vardenafil 20mg how to buy levitra online viagra v levitra best place order levitra

Michaelcaupt says...
anyone use generic viagra viagra for sale uk only take 50 mg viagra viagra for sale uk only buy viagra online using paypal viagra pills buy viagra with overnight shipping viagra pills viagra piller bivirkninger

Richarddiace says...
cheapest cialis generic buy cialis online cheap viagra and cialis cialis tablets buy cialis canada no prescription generic cialis online buying cialis usa cialis generic can you buy cialis over counter usa

Davidphalt says...
sc4 adobe creative suite www.adobereader.com adobe creative adobe flash player windows 10 photoshop cs5 creative loafing adobe photoshop cc 2017 adobe spark

Richardlag says...
adobe reader free download adobe creative cloud download creative cloud adobe adobe creative cloud download cs portable photoshop cs6 http //www.adobe.com adobe photoshop cs6 master collection cs6

MatthewMup says...
cialis pills price generic cialis buy cialis taiwan generic cialis buy now viagra cialis online cialis best place buy cialis online uk buy cialis online order generic cialis india

Francisslals says...
quando il viagra generico buy viagra buy brand viagra online canada viagra online buy sildenafil tablets buy generic viagra online can you buy viagra online australia generic viagra 50 mg viagra vs 100mg viagra

KevinPoxia says...
can take levitra viagra together viagra order viagra salesman jamie ready viagra order viagra online kwikmed online viagra como tomar viagra de 50mg viagra pills efectos secundarios viagra generico

Russellagice says...
where to buy viagra for the brain viagra without prescription online prescriptions for generic viagra viagra prices sildenafil 100mg instructions viagra no prescription cheap viagra online india cheap viagra can you take viagra and antibiotics together

KeithPen says...
can you buy viagra shops viagra current price of viagra viagra online there legal generic viagra generic viagra online de cuantos mg es el viagra buy generic viagra buying viagra online in europe

LeslieWoort says...
can i get an erection without viagra buy viagra online where to buy cheap generic viagra viagra online can i buy viagra online with a prescription over-the-counter viagra can i take 200 mg viagra viagra without a doctor prescription best site to buy generic viagra

Geraldjep says...
sildenafil 50 mg comentarios online prescription can you buy viagra over the counter in us online prescription can you buy viagra at a store online prescriptions order viagra trial online prescriptions viagra canada pharmacy online

Jeffreylig says...
rx party net pill cialis generic cialis tadalafil cheap viagra and cialis generic cialis cialis tablet yan etkileri buy cialis online cheap legitimate cialis online cialis buy cialis online london

Matthewsot says...
CVS Pharmacy albuterol inhaler online pharmacies that do not require a prescription albuterol Online Drugstores levothyroxine medication aarp approved canadian online pharmacies levothyrox online canadian pharmacy

Michaelviact says...
cheap sildenafil online viagra where to buy viagra from online buy viagra priligy and viagra together buy generic viagra online viagra for men price in india generic viagra price viagra nigeria

EdwardGlild says...
buy sildenafil cheap viagra online efectos sildenafil 100mg buy viagra online how easy is it to get viagra from doctor buy generic viagra sildenafil 50 mg o 100 mg buy generic viagra online can you buy viagra in dubai

RichardOptib says...
where to buy viagra in usa viagra without doctor jual viagra generic viagra without a doctor prescription quais os genericos do viagra buy viagra online generico viagra cialis viagra online viagra when generic available

Thomasswell says...
is buying viagra from india safe viagra without prescription pfizer viagra price india viagra without a doctor's prescription is online viagra legal viagra difference between generic and brand name viagra viagra online ordering viagra from overseas

FrankPab says...
online prescription viagra canada viagra without a doctor's prescription can buy viagra usa viagra without a doctor prescription how does a viagra pill look order viagra online yohimbe viagra together buy viagra sildenafil generico patente


Add Comment

Name:
Email:
Comment:

More Health News


Unhealthy and painful: 5 extreme ways to lose weight that you should ..


6 fascinating facts about the human brain ..

- Eye test can now detect early signs of dementia, says study
- From wood splinters to menstruation belt: How sanitary napkins evolved over time
- Decoded: How baby's sex may influence pregnancy complications
- Weight Loss: Top 10 Breakfast Mistakes You Need To Stop Making Today!
- Millennials going overboard to obtain six-pack: Survey
- Sitting for long hours is setting you up for heart risks, diabetes, stress and b
- Express Recipes: 'Bajra Raab'; the natural health drink
- Novel drug may help treat hair loss
- People have realised exercise is best medicine: Zumba star Beto Perez
- Beat the summer heat with this cool 'Orange Cinnamon Tea' recipe
- NHPM set to address health of govt hospitals
- How to lose weight: 6 kinds of easily available foods you MUST eat to shed the k
- Taking vitamin B6 could help you recall dreams
- Laser-based saliva test to help diagnose diseases early
- 170 potential lung cancer drug targets identified
- Is sudden weight loss causing hair loss?
- Kale and beetroot are nutritious ingredients for healthy food
- World Liver Day 2018: Emerging liver health crisis in Kerala, an interplay of ab
- Novel method to help repair damaged ear
- Weight-loss surgery may prevent kidney disease, failure: Study

Related News

World Diabetes Day 2017: Significance and when is the day celebrated
Nov 14:Every year on November 14, different countries observe World Diabetes Day. Started by the International Diabetes Federation .. read more
Plant based diet can be beneficial for diabetes patients
June 19:Plant-based diets can be beneficial for diabetes as a new study has found that it may improve glycemic control, cholestero .. read more
Less sleep may increase diabetes risk in children, says study
Aug 17:Parents, take note! Children who do not get enough night sleep are at a higher risk of developing type 2 diabetes, a study .. read more
Here`s how to keep diabetes at bay
Washington: You may want to keep your blood sugars under control as about 8.1 million diabetes cases go undiagnosed. Since 29.1 mi .. read more
World Diabetes Day 2017: 8 crucial ways to control your blood sugar levels
Nov 12:A disorder of high blood sugar levels, diabetes is spreading its wings to include about 70 million people in India, both in .. read more

More Related News

- Social isolation might raise diabetes risk
- Metformin during pregnancy may up childhood obesity risk
- Novel drug may help treat hair loss
- Vitamin D3 may heal or prevent damage to your heart
- Maternal blood sugar may affect baby's heart
- Pain-free skin patch to automate diabetes management
- Women with larger waistline are at higher risk of anxiety
- Novel method to help repair damaged ear
- Weight-loss surgery may prevent kidney disease, failure: Study
- Beware of diet fads! Why gluten-free food can increase risk of diabetes

More Latest News:

- Musi clean-up gains pace
- TS issues guidelines for implementing Economic Support Schemes
- Telangana will protect sericulture farmers, says Etela Rajender
- Global meet on blockchain in Hyderabad
- 200 check dams coming up in Telangana
- Fighting rain, flood for Medigadda dream
- Break silos, make government seamless for people: President Kovind to newly recruited IAS officers
- PM Narendra Modi wishes former Tamil Nadu CM Karunanidhi speedy recovery
- Ahmedabad 2008 serial blasts accused gets bail
- Congress leader Jairam writes to NMML director over confusion for museum approval
- PNB scam: Fugitive jeweller Mehul Choksi says he took Antigua citizenship last year to expand business
- Eye test can now detect early signs of dementia, says study
- India vs Essex Practice Match: India's frontmen dazzle, sidekicks falter
- Hopeful to be part of England squad in World Cup 2022, says Phil Foden
- Twenty young boys and girls to represent India at Junior NBA World Championship
- Mission: Impossible Fallout box office prediction: The Tom Cruise film will earn Rs 10 crore on Day 1
- Saheb Biwi Aur Gangster 3 movie review: The weakest link is Sanjay Dutt's gangster
- Saudi Arabia joins global pledge to protect disabled rights
- Iran's Revolutionary Guards' chief warns Trump: 'If you begin the war, we will end it'
- Houthis accused of threatening world's electricity supplies
- Youth, woman held for murder
- Rahul Gandhi congratulates ragpicker's son for cracking AIIMS entrance test
- Cows are safer than women in the country, says Shiv Sena chief Uddhav Thackeray
- Bihar clears new liquor bill, CM Nitish says prohibition for betterment of poor
- 'Do not stop writing': Kerala CM Pinarayi Vijayan backs writer Hareesh over novel controversy
This page was created in 0.0255270004272 seconds