170 potential lung cancer drug targets identified

April 23:Scientists, who tested over 200,000 chemical compounds, have identified 170 candidates that can be potentially used for developing new drug therapies for lung cancer.
The five-year project set out to identify new therapeutic targets for non-small cell lung cancer as well as potential drugs for these targets - a significant step forward towards personalising cancer care, researchers said.
For the large majority of compounds, we identified a predictive biomarker - a feature that allows the development of precision medicine, or individualised treatment for each patient," said John Minna, from University of Texas in the US.
For the study, published in the journal Cell, the researchers searched for compounds that would kill cancer cells but not harm normal lung cells.
"We began an ambitious project with the goal of identifying therapeutic triads: chemicals that kill cancer cells, biomarkers that predict who would respond, and the therapeutic targets on which those active chemicals work," said Minna.
Continuing to uncover the mechanism of action for the majority of the 170 chemicals will be a key focus of future research. Follow-up work will also include testing the chemicals on other types of cancer. Preliminary work shows some of the compounds are likely effective against certain breast and ovarian cancers as well.
The researchers have carefully developed and curated a collection of lung cancer cell lines since the 1970s that is now recognised as the worlds largest.
The team of scientists began by testing 200,000 chemicals against 12 lung cancer cell lines.
"The initial screen gave us 15,000 chemical hits, way too many to work with in detail, but with repeat testing we eventually narrowed the number down to 170," said Bruce Posner, Professor of Biochemistry and Director of the High-Throughput Center at University of Texas.
The set of 170 chemical compounds was then tested across 100 lung cancer lines.
At the same time, researchers conducted in-depth molecular analyses of the lung cancer lines, including identification of genome mutations and protein expression.
This information, paired with whether or not an individual cancer cell line was sensitive to a particular chemical, allowed the researchers to develop a set of biomarkers - indicators that could be used to determine if a particular cancer will respond to one of the 170 chemical compounds. Agencies
Source: Agencies


  
  

Comments


No comments yet! Be the first one to leave a comment.


Add Comment

Name:
Email:
Comment:

More Health News


Unhealthy and painful: 5 extreme ways to lose weight that you should ..


6 fascinating facts about the human brain ..

- Eye test can now detect early signs of dementia, says study
- From wood splinters to menstruation belt: How sanitary napkins evolved over time
- Decoded: How baby's sex may influence pregnancy complications
- Weight Loss: Top 10 Breakfast Mistakes You Need To Stop Making Today!
- Millennials going overboard to obtain six-pack: Survey
- Sitting for long hours is setting you up for heart risks, diabetes, stress and b
- Express Recipes: 'Bajra Raab'; the natural health drink
- Novel drug may help treat hair loss
- People have realised exercise is best medicine: Zumba star Beto Perez
- Beat the summer heat with this cool 'Orange Cinnamon Tea' recipe
- NHPM set to address health of govt hospitals
- How to lose weight: 6 kinds of easily available foods you MUST eat to shed the k
- Taking vitamin B6 could help you recall dreams
- Laser-based saliva test to help diagnose diseases early
- 170 potential lung cancer drug targets identified
- Is sudden weight loss causing hair loss?
- Kale and beetroot are nutritious ingredients for healthy food
- World Liver Day 2018: Emerging liver health crisis in Kerala, an interplay of ab
- Novel method to help repair damaged ear
- Weight-loss surgery may prevent kidney disease, failure: Study

Related News

Air pollution may up mortality risk beyond lung cancer: Study
Nov 1:Long-term exposure to air pollution may not only lead to lung cancer, but also increase the risk of mortality from kidney, b .. read more
Key anti-cancer drug Erubulin to be affordable now
Hyderabad, Jan 26:A landmark breast cancer drug that so far remained out of reach of underprivileged patients in the country is se .. read more
CSIR-NCL develops promising cocrystal drug for treatment of tuberculosis
May 7:CSIR-National Chemcial Laboratory (NCL) has developed an anti-tuberculosis cocrystal drug, pitched to be a promising one thr .. read more
Eating hot dogs, bacon may up colorectal cancer risk
Sept 8:Love to gorge on hot dogs, bacon, ham, sausages and salami? Beware, you may be at an increased risk of developing colorecta .. read more
Serbian police arrest 3 Australians over $400M cocaine haul
Canberra, Australia:Three Australians have been arrested in Serbia over the second-largest cocaine haul in Australian law enforcem .. read more

More Related News

- Single blood test may detect eight types of cancer: study
- Single blood test may detect eight types of cancer: study
- Novel drug may help treat hair loss
- Night shift may put women at increased cancer risk: study
- The Real Cause of Cancer: Is it Pure Bad Luck? Science Answers
- Novel method to help repair damaged ear
- KTR is having links with drug peddlers: Revanth
- World Running Out Of Antibiotics, Warns World Health Organisation
- Diabetes drug may help treat Alzheimer's: study
- Vitamin in milk could prevent pain caused by chemotherapy

More Latest News:

- Musi clean-up gains pace
- TS issues guidelines for implementing Economic Support Schemes
- Telangana will protect sericulture farmers, says Etela Rajender
- Global meet on blockchain in Hyderabad
- 200 check dams coming up in Telangana
- Fighting rain, flood for Medigadda dream
- Break silos, make government seamless for people: President Kovind to newly recruited IAS officers
- PM Narendra Modi wishes former Tamil Nadu CM Karunanidhi speedy recovery
- Ahmedabad 2008 serial blasts accused gets bail
- Congress leader Jairam writes to NMML director over confusion for museum approval
- PNB scam: Fugitive jeweller Mehul Choksi says he took Antigua citizenship last year to expand business
- Eye test can now detect early signs of dementia, says study
- India vs Essex Practice Match: India's frontmen dazzle, sidekicks falter
- Hopeful to be part of England squad in World Cup 2022, says Phil Foden
- Twenty young boys and girls to represent India at Junior NBA World Championship
- Mission: Impossible Fallout box office prediction: The Tom Cruise film will earn Rs 10 crore on Day 1
- Saheb Biwi Aur Gangster 3 movie review: The weakest link is Sanjay Dutt's gangster
- Saudi Arabia joins global pledge to protect disabled rights
- Iran's Revolutionary Guards' chief warns Trump: 'If you begin the war, we will end it'
- Houthis accused of threatening world's electricity supplies
- Youth, woman held for murder
- Rahul Gandhi congratulates ragpicker's son for cracking AIIMS entrance test
- Cows are safer than women in the country, says Shiv Sena chief Uddhav Thackeray
- Bihar clears new liquor bill, CM Nitish says prohibition for betterment of poor
- 'Do not stop writing': Kerala CM Pinarayi Vijayan backs writer Hareesh over novel controversy
This page was created in 0.0225791931152 seconds