CSIR-NCL develops promising cocrystal drug for treatment of tuberculosis

May 7:CSIR-National Chemcial Laboratory (NCL) has developed an anti-tuberculosis cocrystal drug, pitched to be a promising one through its stable formulation of 4-FDC (4 drugs fixed dosage). Tuberculosis is still rampant among Indians and is one of the main killer diseases globally.
As per the recommendation by the World health Organisation (WHO), Rifampicin (RIF), Isoniazid (INH), Pyrazinamide (PZA), and Ethambutol dihydrochloride (EDH) drugs are used for the treatment of TB. The use of fixed dose combination (2-drug, 3-drug and 4-drug FDCs) for the treatment of tuberculosis was first recommended in 1994 by the WHO and International Union against Tuberculosis and Lung Disease (IUATLD).
In 1999, the 4-drug FDC tablet was included in the WHO Model List of Essential Drugs inclusive of these four drugs. The 4-FDC tablets, however, had quality and stability issues, including poor bio-availability of Rifampicin and instability during its storage, which raised concerns on the utility of this FDC. It was essential to address the quality and stability issues.
The team of NCL researchers, led by Prof A K Nangia, studied the reasons for instability caused to 4-FDC chemical structures. The researchers developed pharmaceutically stable cocrystals so that the drug would not form any by-products even while it would inhibit cross-section between Isoniazid and Rifampicin. The team demonstrated a five-fold increased stability levels in the newly devised cocyrstal combination meant for TB. Sharing the biggest advantage, Nangia said, "Stable cocrystal drug with longer shelf life will improve the prospects of transport logistics and inventory management of TB drugs." Agencies
Source: Agencies


  
  

Comments


No comments yet! Be the first one to leave a comment.


Add Comment

Name:
Email:
Comment:

More Entertainment News


Priyanka Chopra visits Rohingya refugee camps in Bangladesh, appeals f ..


Priyanka Chopra visits Rohingya refugee camps in Bangladesh, appeals f ..

- Race 3: Salman Khan turns lyricist for song Selfish. Here's how
- Aamir Khan on his earlier films: I was constantly swimming against the tide
- Was Aditya Chopra's triumph with Dilwale Dulhania Le Jayenge just a stroke of lu
- Sonam Kapoor on changing her name after marriage: Anand has also changed his nam
- Manto early reviews: The Nawazuddin Siddiqui starrer opens to positive response
- Meghna Gulzar on Raazi's release in Pakistan: Cultural exchanges should not be d
- Cannes Film Festival 2018: Indian delegation to push Village Rockstars, Nagarkir
- Madhuri Dixit: I'm excited to work with Anil Kapoor and Sanjay Dutt again
- Dia Mirza on working in Sanju: I was terrified to be in front of the camera afte
- Richa Chadha on Ali Fazal: We are just two normal people in a relationship
- Fully support severe punishment to those who assault children: Anushka Sharma
- Total Dhamaal: Anil Kapoor, Madhuri Dixit to match steps on the remixed version
- Javed Akhtar distributes Rs 13 crore worth TV synchronisation royalty to musicia
- Deepika Padukone and Ranbir Kapoor turn heads at Mijwan Fashion Show 2018
- Screaming nepotism after Student of the Year 2 posters? It's a lost cause
- Writer Juhi Chaturvedi on October: Varun Dhawan's Dan is the kind of character w
- Student Of The Year 2: All your questions about the Karan Johar film answered
- Divya Bharti, the promising Saat Samundar Paar girl who passed away at 19
- Baaghi 2 movie review: The Tiger Shroff film has more fight than bite

Related News

Key anti-cancer drug Erubulin to be affordable now
Hyderabad, Jan 26:A landmark breast cancer drug that so far remained out of reach of underprivileged patients in the country is se .. read more
WHO Warns About Lack of Antibiotics: Immunity Boosting Foods for the Flu Season
Oct 28:A report released by World Health Organisation (WHO) has stated some shocking facts. According to it, antibiotics that are .. read more
Garlic can fight chronic infections
Nov 28:Garlic may help fight chronic infections, according to a study that shows ajoene, an active sulphurous compound found in th .. read more
Loophole in HIV/AIDS Bill passed by Rajya Sabha draws criticism from patients, health experts
Mar 22:Indian legislators lost an opportunity on Tuesday to really make a difference to thousands of people living with HIV and AI .. read more
Serbian police arrest 3 Australians over $400M cocaine haul
Canberra, Australia:Three Australians have been arrested in Serbia over the second-largest cocaine haul in Australian law enforcem .. read more

More Related News

- World Tuberculosis Day: Know the symptoms and treatments of the airborne disease
- Diabetes drug may help treat Alzheimer's: study
- Novel drug may help treat hair loss
- World Running Out Of Antibiotics, Warns World Health Organisation
- Metformin during pregnancy may up childhood obesity risk
- KTR is having links with drug peddlers: Revanth
- Science is important for the betterment of life: Vice President
- Vitamin D3 may heal or prevent damage to your heart
- Another drug racket busted
- Kukatpally murder: Did slain businessman peddle drugs?

More Latest News:

- Om Mitharval, Jitu Rai off the mark at Munich World Cup
- NBA Playoffs: LeBron James scores 46 as Cavaliers force Game 7 in Boston
- Somali leader urges calm after clashes in disputed north
- KSA, Vatican playing major role in defeating extremism: Interfaith official
- Powerful Cyclone Mekunu leaves at least 3 dead, 40 missing in Oman and Yemen
- CM Palaniswami defends police firing, says natural course against attack
- After PM Modi accepts fitness challenge, Rahul Gandhi throws another at him: 'Reduce fuel prices or face nationwide agitation'
- Shashi Tharoor tells Congress not to be embarrassed by cash crunch, suggests how to take on BJP's 'moneybags'
- Fissures in MP Congress unit ahead of party president Rahul Gandhi's visit
- Nipah virus claims one more life in Kerala, death toll rises to 12
- J&K: Lull in border firing after nine days
- KTR directs HMWSSB to complete road restoration works by June 15
- Schools in Telangana to reopen on June 1
- KTR calls for cooperation between public and private health care sector
- Delay in desiltation works worrying GHMC corporators
- Telangana to fill vacant posts in NIMS
- Hyderabad-based UDo will answer all your queries
- Telangana to launch e-mobility policy in June, says Jayesh
- Andres Iniesta signs with Japan's Vissel Kobe
- While Neymar continues recovery, Douglas Costa picks up injury
- Russians to take no part in World Cup drug testing: FIFA
- Race 3: Salman Khan turns lyricist for song Selfish. Here's how
- Aamir Khan on his earlier films: I was constantly swimming against the tide
- Malaysia's ex-leader Najib Razak questioned again in corruption scandal
- Thailand arrests senior monks in temple raids to clean up Buddhism
This page was created in 0.022216796875 seconds